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Research Database

Peptide Studies

Key clinical trials and research studies, evidence-graded and internally linked to compound profiles.

23
Studies indexed
9
Phase III RCTs
16
Compounds covered
41k+
Total participants
Landmark Trials

Start with the studies that shape the conversation

These pivotal trials carry the strongest downstream impact on how the rest of the database gets interpreted.

EL1SELECT2023·New England Journal of Medicine
N=17,604

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

Lincoff AM, Brown-Frandsen K, Colhoun HM, et al.

Semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% versus placebo in overweight or obese adults with estab...

EL1SURMOUNT-12022·New England Journal of Medicine
N=2,539

Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)

Jastreboff AM, Aronne LJ, Ahmad NN, et al.

Tirzepatide 15 mg once-weekly produced a mean body weight reduction of 22.5% versus 2.4% with placebo in adults with obesity without diab...

EL1STEP-12021·New England Journal of Medicine
N=1,961

Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP-1)

Wilding JPH, Batterham RL, Calanna S, et al.

Semaglutide 2.4 mg once-weekly produced 14.9% mean body weight reduction versus 2.4% with placebo in adults with obesity without diabetes.

EL1RECONNECT2016·Women's Health
N=1,247

Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women (RECONNECT)

Clayton AH, Althof SE, Kingsberg S, et al.

Bremelanotide (PT-141) 1.75 mg SC increased satisfying sexual events by 0.7 per month versus 0.4 for placebo and significantly reduced di...

EL1LEADER2016·New England Journal of Medicine
N=9,340

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes (LEADER)

Marso SP, Daniels GH, Brown-Frandsen K, et al.

Liraglutide 1.8 mg daily reduced MACE by 13% versus placebo in type 2 diabetes patients at high cardiovascular risk.

EL1SUSTAIN-62016·New England Journal of Medicine
N=3,297

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6)

Marso SP, Bain SC, Consoli A, et al.

Once-weekly semaglutide reduced the rate of cardiovascular death, nonfatal MI, or nonfatal stroke by 26% versus placebo in patients with ...

Complete Index

All Studies

Sorted by year, newest first. Landmark trials stay visually separate so the main index remains easier to scan.

17 studies in the complete index
EL1 - Phase III RCT EL2 - Phase I/II Human EL3 - Animal / Limited EL4 - Anecdotal
EL32021·World Journal of Gastroenterology
0

Cytoprotective Activities of Gastric Pentadecapeptide BPC 157 in Three Different Cell L...

Sikiric P, Rucman R, Turkovic B, et al.

BPC-157 protected gastric, intestinal, and liver cell lines from ethanol, NSAIDs, and oxidative stress damage, with concurrent reversal o...

EL22020·Clinical Infectious Diseases
N=76

Thymosin Alpha-1 (Tα1) Reduces the Mortality of Severe COVID-19 by Restoration of Lymph...

Wu H, Chen Y, Li Y, et al.

Thymosin Alpha-1 1.6 mg twice-daily SC significantly reduced 28-day mortality (11.1% vs. 30.0%) and ICU duration in severe COVID-19 patie...

EL32018·Current Pharmaceutical Design
0

Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract

Sikiric P, Seiwerth S, Rucman R, et al.

BPC-157 consistently accelerated tendon, ligament, bone, and GI mucosal healing across multiple animal model studies, and exhibited a bro...

EL22016·Biochemistry (Moscow)
N=190

Semax, an Analog of ACTH(4-10) with Long-Lasting Anxiolytic and Nootropic Activity, Sti...

Gudasheva TA, Tarasiuk AV, Pauls I, et al.

Semax nasal spray significantly improved neurological function scores (NIHSS) and reduced early neurological deficit in ischemic stroke p...

EL1SCALE Obesity2015·New England Journal of Medicine
N=3,731

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management (SCALE Obe...

Pi-Sunyer X, Astrup A, Fujioka K, et al.

Liraglutide 3.0 mg daily produced a mean weight loss of 8.4% versus 2.8% with placebo in adults with obesity, leading to FDA approval of ...

EL32012·Neuro Endocrinology Letters
N=266

15-Year Follow-Up Study of the Effects of Epithalon on Mortality in Elderly Patients

Khavinson VKh, Izmaylov DM, Obukhova LK, Malinin VV.

Elderly patients who received epitalon showed a 28% reduction in mortality over 15-year follow-up compared to controls not receiving the ...

EL32012·Oxidative Medicine and Cellular Longevity
0

The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditio...

Pickart L, Vasquez-Soltero JM, Margolina A.

Comprehensive review documenting GHK-Cu's stimulation of collagen synthesis (12 types), angiogenesis, wound contraction, and anti-inflamm...

EL22010·Journal of Clinical Endocrinology & Metabolism
N=292

Effects of Tesamorelin (a Growth Hormone–Releasing Factor Analog) and MK-677 on Body Co...

Falutz J, Mamputu JC, Potvin D, et al.

MK-677 25 mg daily significantly increased lean body mass and decreased visceral fat in HIV-positive patients with adipose redistribution...

EL22010·Bulletin of Experimental Biology and Medicine
N=62

Anxiolytic Activity of Selank and Tuftsin in Generalized Anxiety Disorder: A Double-Bli...

Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskiy VI.

Selank (0.15 mg nasal twice daily) reduced Hamilton Anxiety Rating Scale scores by 38% versus 20% for placebo in generalized anxiety diso...

EL22008·Expert Opinion on Biological Therapy
N=140

Thymosin Alpha-1 for the Treatment of Immunocompromised Patients: Restoration of CD4 Co...

Romano Carratelli C, Mazzola N, Monticelli F, et al.

Thymosin Alpha-1 administration restored CD4+ T-cell counts and shifted the cytokine profile toward TH1 predominance in immunocompromised...

EL12006·New England Journal of Medicine
N=122

Randomized Controlled Trial of the Effects of Testosterone and Growth Hormone Supplemen...

Nair KS, Rizza RA, O'Brien P, et al.

Growth hormone supplementation improved body composition (lean mass +2.0 kg, fat −2.4 kg) in older men regardless of testosterone status,...

EL22006·Journal of Clinical Endocrinology & Metabolism
N=65

Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion...

Teichman SL, Neale A, Lawrence B, et al.

CJC-1295 (a GHRH analog) produced dose-dependent GH pulses lasting up to 8 days per injection and sustained IGF-1 elevations 1.5–3x basel...

EL32005·Trends in Molecular Medicine
0

Actin-Sequestering Proteins and the Thymosin Beta-4 Peptide: Functions and Therapeutic ...

Goldstein AL, Hannappel E, Kleinman HK.

Thymosin Beta-4 (TB-500) promotes wound healing, angiogenesis, and cardiac repair through actin sequestration and cell migration mechanis...

EL32003·Bulletin of Experimental Biology and Medicine
N=14

Peptide Regulation of Aging: Effect of Epithalon on Telomere Length and Oxidative Damag...

Khavinson VKh, Bondarev IE, Butyugov AA.

Epitalon treatment increased telomere length and reduced 8-OHdG oxidative DNA damage markers in peripheral blood lymphocytes of elderly v...

EL1DHEAge2000·Proceedings of the National Academy of Sciences
N=280

Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Stud...

Baulieu EE, Thomas G, Legrain S, et al.

DHEA 50 mg daily for 12 months significantly improved bone mineral density in women over 70 and enhanced skin hydration, sebum production...

EL31998·European Journal of Endocrinology
0

Ipamorelin, the First Selective Growth Hormone Secretagogue

Raun K, Hansen BS, Johansen NL, et al.

Ipamorelin produced selective, dose-dependent GH release with no effect on cortisol, prolactin, or ACTH at any dose tested — distinguishi...

EL21996·Journal of Clinical Endocrinology & Metabolism
N=32

Stimulation of the Growth Hormone (GH)-Insulin-Like Growth Factor I Axis by Daily Oral ...

Chapman IM, Bach MA, Van Cauter E, et al.

Oral GH secretagogue MK-677 increased GH pulse amplitude and 24-hour IGF-1 concentrations to young-adult levels in healthy elderly subjec...